English Arabic Chinese (Simplified) French German Greek Italian Polish Portuguese Russian Spanish
  • This email address is being protected from spambots. You need JavaScript enabled to view it.
  • +44 (0) 161 877 2334

Clostridium Difficile - A Guide to the Bacterium

Clostridium Difficile - A Guide to the Bacterium

This guide explains what Clostridium difficile is, how it developed and ways in which it can cause infection.

Clostridium difficile is the major cause of antibiotic-associated diarrhoea and colitis, a healthcare associated intestinal infection that mostly affects elderly patients with other underlying diseases.

C. difficile is a bacterium of the family Clostridium (the family also includes the bacteria that cause tetanus, botulism, and gas gangrene). It is an anaerobic bacterium (i.e. it does not grow in the presence of oxygen) and produces spores that can survive for a long time in the environment.

Its usual habitat is the large intestine, where there is very little oxygen. It can be found in low numbers in a small proportion (less than 5%) of the healthy adult population. It is kept in check by the normal, ‘good’ bacterial population of the intestine.

It is common in the intestine of babies and infants, but does not cause disease because its toxins (poisons) do not damage their immature intestinal cells.    

Although C. difficile was first described in the 1930s, it was not identified as the cause of diarrhoea and colitis following antibiotic therapy until the late 1970s.

What does C. difficile cause?

C. difficile can cause diarrhoea, ranging from a mild disturbance to a very severe illness with ulceration and bleeding from the colon (colitis) and, at worst, perforation of the intestine leading to peritonitis. It can be fatal.

Generally, it is only able to do this when the normal, healthy intestinal bacteria have been killed off by antibiotics. When not held back by the normal bacteria, it multiplies in the intestine and produces two toxins (A and B) that damage the cells lining the intestine. The result is diarrhoea.

Who gets C. difficile infection?

Patients who have been treated with broad spectrum antibiotics (those that affect a wide range of bacteria, including intestinal bacteria) are at greatest risk of C. difficile disease. Most of those affected are elderly patients with serious underlying illnesses. Most infections occur in hospitals (including community hospitals), nursing homes etc, but it can also occur in primary care settings.

How does it spread?

Although some people can be healthy carriers of C. difficile, in most cases the disease develops after cross infection from another patient, either through... request a copy of the full document >>

Extracted from a guide originally published by the Department of Health - © Crown copyright

Clostridium Difficile Guide Request

To receive a full copy of this guide please complete and submit this form:

Please let us know your name.

Please let us know your email address.

Please write a subject for your message.

Invalid Input

Please let us know your message.

Invalid Input
Invalid Input

World Class Expertise

Accepta work with industry worldwide delivering practical, cost effective solutions to resolve complex problems. If you require technical assistance, or information about our water treatment chemicals and other speciality products, please contact our dedicated technical support team on:

+44 (0) 845 519 89 90 or complete our Technical Support form.

Expert Training

Develop your skills with our internationally recognised water and wastewater treatment training courses. Delivered by world leading industry experts and designed for engineers, facilities managers and environmental professionals... water treatment training.

Keep upto date with our extensive library of good practice guides, latest research, regulatory updates, news and more... knowledge base.

Custom Chemical Manufacturing

Accepta offer custom chemical manufacturing, specialist toll blending and white label production services for our own water treatment chemicals and client specific formulations to UK and international customers.

To discover how you could benefit from our environmentally sensitive, quality driven chemical manufacturing capabilities please call us on +44 (0) 161 877 2334 or contact us.

International Distributor Opportunities

Accepta's innovative, quality driven customer focused business model creates exciting global supply chain and distributor opportunities for established and ambitious businesses currently active within the water treatment, wastewater treatment and environmental services sectors around the world.

If you are interested in becoming an exclusive international distributor of Accepta water treatment technologies please click here to learn more.

bsi-ukas-14001-2004bsi-ukas-9001-2008british-association-for-chemical-specialitiesinvestors-in-people-iip  greater-manchester-chamber-of-commerce-member